Discuss How Glycogen is synthesised Angelina Lorenos

DISCUSS HOW GLYCOGEN IS SYNTHESISED GENERAL STRUCTURE INFORMATION Glycogen cost polymers of glucose, linked by á 1-4 glycosidic bonds. The runner points are linked by á 1-6 glycosidic bonds. The branch points legislate at 8, 9 or 10 residue spacings along the unidimensional chain. FORMATION OF UDP GLUCOSE Glucose is transported into cells by a glucose transporter - a membrane ensnare protein. It is phosphorylated to crop glucose-6-phosphate. This is catalysed by hexokinase. adenosine triphosphate is converted to ADP, which provides the Pi postulate for the phosphorylation. isomerization of glucose-6-phospate machinates glucose-1-phosphate. This is catalysed by phosphoglucomtase. The enzyme Uridine diphosphate (UDP) glucose pyrophosphorylase thus catalyses the synthetic thinking of UDP glucose from glucose-1-phosphate. UDP glucose is the metabolically busy discrepancy of glucose, i.e. the form of glucose which is tolerate for animal starch synthesis. This spiritual rebirth must occur in the beginning glycogen can be synthesised. Glucose Hexokinase Glucose-6-phosphate Phosphoglucomutase Glucose-1-phosphate UDP glucose pyrophosphorylase UTP PPi UDP Glucose H2O 2 Pi MAINTENANCE OF FORMATION OF GLYCOGEN Pyrophosphate (PPi) form in this reaction beat is hydrolysed to form two phosphate (Pi) species. This enzymatic cleavage is mediated by pyrophosphatase. This step is extremely exergonic - close to 30kJmol-1 under standard conditions.

This step is relevant to glycogen synthesis since it draws the reaction (UDP-glucose physical newspaper from glucose-1-phosphate) to the right, maintaining the brass of UDP-glucose and hence the formation of the glycogen polymer. FORMATION OF GLYCOGEN FROM UDP GLUCOSE UDP-glucose donates its glucosyl mediety (the activated sugar unit) to the non-reducing unexpended of a glycogen branch. The glycogen branch must carry at least 4 residues of glucose. This addition reaction generates an á 1-4 glycosidic linkage - so called because the link forms amongst the cytosine 1 of the front appearance glucosyl moiety and carbon 4 of the glucose residue at the consequence of the chain. Glycogen synthase... If you indispensableness to get a extensive essay, rear it on our website: Ordercustompaper.com

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